Impact of amyloid polymorphism on prion-chaperone interactions in yeast
Downloadable Content
Abstract
- Yeast prions are protein-based genetic elements found in the baker’s yeast
Saccharomyces cerevisiae, most of which are amyloid aggregates that propagate by fragmentation
and spreading of small, self-templating pieces called propagons. Fragmentation is carried out by
molecular chaperones, specifically Hsp104, Hsp70, and Hsp40. Like other amyloid-forming proteins,
amyloid-based yeast prions exhibit structural polymorphisms, termed “strains” in mammalian
systems and “variants” in yeast, which demonstrate diverse phenotypes and chaperone requirements
for propagation. Here, the known di erential interactions between chaperone proteins and yeast
prion variants are reviewed, specifically those of the yeast prions [PSI+], [RNQ+]/[PIN+], and [URE3].
For these prions, di erences in variant-chaperone interactions (where known) with Hsp104, Hsp70s,
Hsp40s, Sse1, and Hsp90 are summarized, as well as some interactions with chaperones of other
species expressed in yeast. As amyloid structural di erences greatly impact chaperone interactions,
understanding and accounting for these variations may be crucial to the study of chaperones and
both prion and non-prion amyloids.
| Title | Impact of amyloid polymorphism on prion-chaperone interactions in yeast |
|---|---|
| Creator | Miller, S. C. |
| Killian, A. N. | |
| Hines, Justin K. | |
| Publisher | Viruses |
| Academic Department | Chemistry |
| Division | Natural Sciences |
| Organization | Lafayette College |
| Date Issued | 2019 |
| Date Available | 2019-04-22T14:58:26Z |
| Type | Article |
| Language | English |
| Keyword | Apj1 |
| Swa2 | |
| Ydj1 | |
| J-protein | |
| Ssa | |
| Ssb | |
| Sis1 | |
| Hdj1 | |
| Bibliographic Citation | Killian, A. N., S. C. Miller, and J. K. Hines (2019) "Impact of amyloid polymorphism on prion-chaperone interactions in yeast." Viruses 11: 349. |
| Standard Identifier | DOI 10.3390/v11040349 |
| Handle 10385/2847 | |
| Permalink | http://hdl.handle.net/10385/2847 |
| Rights Statement |
Creative Commons - Attribution
|
| Rights Holders | Miller, S. C. |
| Killian, A. N. | |
| Hines, Justin K. |
Contains
| File | Hines-Viruses-vol11-2019.pdf | Uploaded 2019-10-20 | Public | Download |
Member of Collection
