FTY720 promotes local microvascular network formation and regeneration of cranial bone defects

DSpace/Manakin Repository

FTY720 promotes local microvascular network formation and regeneration of cranial bone defects

Show simple item record


dc.contributor.author Aronin, C. E. P.
dc.contributor.author Sefcik Anderson, Lauren
dc.contributor.author Tholpady, S. S.
dc.contributor.author Tholpady, A.
dc.contributor.author Sadik, K. W.
dc.contributor.author MacDonald, T. L.
dc.contributor.author Peirce, S. M.
dc.contributor.author Wamhoff, B. R.
dc.contributor.author Lynch, K. R.
dc.contributor.author Ogle, R. C.
dc.contributor.author Botchwey, E. A.
dc.date.accessioned 2011-02-07T19:52:42Z
dc.date.available 2011-02-07T19:52:42Z
dc.date.issued 2010-06
dc.identifier.citation Aronin, C. E. P., et. al. (2010) "FTY720 promotes local microvascular network formation and regeneration of cranial bone defects." Tissue Engineering Part A 16 (6): 1801-1809. en_US
dc.identifier.uri http://hdl.handle.net/10385/800
dc.description.abstract The calvarial bone microenvironment contains a unique progenitor niche that should be considered for therapeutic manipulation when designing regeneration strategies. Recently, our group demonstrated that cells isolated from the dura are multipotent and exhibit expansion potential and robust mineralization on biodegradable constructs in vitro. In this study, we evaluate the effectiveness of healing critical-sized cranial bone defects by enhancing microvascular network growth and host dura progenitor trafficking to the defect space pharmacologically by delivering drugs targeted to sphingosine 1-phosphate (S1P) receptors. We demonstrate that delivery of pharmacological agonists to (S1P) receptors S1P(1) and S1P(3) significantly increase bone ingrowth, total microvessel density, and smooth muscle cell investment on nascent microvessels within the defect space. Further, in vitro proliferation and migration studies suggest that selective activation of S1P(3) promotes recruitment and growth of osteoblastic progenitors from the meningeal dura mater. en_US
dc.publisher Tissue Engineering Part A en_US
dc.title FTY720 promotes local microvascular network formation and regeneration of cranial bone defects en_US
dc.type Article en_US
dc.identifier.doi 10.1089/ten.tea.2009.0539

Files in this item

Files Size Format View
Anderson-TissueEngineeringA-vol16-2010.pdf 672.6Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

Search LDR


Advanced Search

Browse

My Account