Altered protein expression in the ileum of mice associated with the development of chronic infections with Echinostoma caproni (Trematoda)
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Abstract
- Intestinal helminth infections are among the most prevalent parasitic diseases and about 1
billion people are currently infected with intestinal helminths. Incidence of intestinal helminth
infections is high due to both socio-economic factors that facilitates continuous reinfections
and the lack of effective vaccines. In this context, further knowledge on the
host-parasite relationships is required to elucidate the factors that determine the expulsion
of the intestinal helminths or, in contrast, the chronic establishment of the infections.
Echinostoma caproni (Trematoda) is an intestinal trematode that has been extensively
used as experimental model to investigate these factors. Depending on the host species. E.
caproni is rapidly rejected or develops chronic infections. Herein, we analyze the changes
in protein expression induced by E. caproni infection in a host in which the parasites
develop chronic infections. These data may serve to get a better understanding of the factors
determining the development of chronic intestinal infections. A total of 37 spots were
identified differentially expressed. These proteins were related to the restoration of the
intestinal epithelium and the control of homeostatic dysregulation, mitochondrial and
cytoskeletal proteins among others. This suggests that the changes in these processes in
the intestinal mucosa may facilitate the development of chronic infections.
| Title | Altered protein expression in the ileum of mice associated with the development of chronic infections with Echinostoma caproni (Trematoda) |
|---|---|
| Creator | Fried, Bernard |
| Muñoz-Antoli, C. | |
| Esteban, J. G. | |
| Toledo, R. | |
| Sotillo, J. | |
| Cortes, A. | |
| Publisher | PLoS Neglected Tropical Diseases |
| Academic Department | Biology |
| Division | Natural Sciences |
| Organization | Lafayette College |
| Date Issued | September 2015 |
| Date Available | 2015-10-22T15:31:25Z |
| Type | Article |
| Language | English |
| Bibliographic Citation | Cortes, A., et al. (2015 Sept.) "Altered protein expression in the ileum of mice associated with the development of chronic infections with Echinostoma caproni (Trematoda)." PLoS Neglected Tropical Diseases 9(9): e0004082. |
| Standard Identifier | Handle 10385/2045 |
| DOI 10.1371/journal.pntd.0004082 | |
| Permalink | http://hdl.handle.net/10385/2045 |
| Rights Statement |
Creative Commons - Attribution
|
| Rights Holders | Fried, Bernard |
| Muñoz-Antoli, C. | |
| Esteban, J. G. | |
| Toledo, R. | |
| Sotillo, J. | |
| Cortes, A. |
Contains
| File | Fried-PLOSNeglectedTropicalDiseases-2015.pdf | Uploaded 2019-10-20 | Public | Download |
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