Trematocidal activity of praziquantel and artemisinin derivatives: In vitro and in vivo investigations with adult Echinostoma caproni

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Abstract
  • We examined the effects of praziquantel and the artemisinins on adult Echinostoma caproni. In vitro, both praziquantel and the artemisinins exhibited exposure-response relationships. In vivo, worm burden reductions of 100% were achieved with single oral doses of praziquantel, artesunate, and artemether at 50, 700, and 1,100 mg/kg of body weight, respectively.
TitleTrematocidal activity of praziquantel and artemisinin derivatives: In vitro and in vivo investigations with adult Echinostoma caproni
CreatorFried, Bernard
Utzinger, J.
Keiser, J.
Brun, R.
PublisherAntimicrobial Agents and Chemotherapy
Academic DepartmentBiology
DivisionNatural Sciences
OrganizationLafayette College
Date Issued2006
Date Available2015-06-05T15:42:11Z
TypeArticle
LanguageEnglish
Bibliographic CitationKeiser, J., et al. (2006) " Trematocidal activity of praziquantel and artemisinin derivatives: In vitro and in vivo investigations with adult Echinostoma caproni." Antimicrobial Agents and Chemotherapy 50 (2): 803-805.
Standard IdentifierHandle 10385/1983
DOI 10.1128/AAC.50.2.803-805.2006
Permalinkhttp://hdl.handle.net/10385/1983
Rights Statement In Copyright In Copyright
Rights HoldersAmerican Society for Microbiology
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