Evidence of altered secondary lymphoid-tissue chemokine responsiveness in Balb/c mice infected with Schistosoma mansoni

To determine the extent to which splenic T cells were affected by Schistosoma mansoni infection. we investigated the ability of the T cells to produce interferon (IFN)-gamma, as well as their chemotactic ability 7 wk PI. In this study, we report that splenic T cells from Balb/c mice with S. mansoni infections were capable of producing levels of IFN-gamma comparable with splenic T cells from naive mice. However, the T cells exhibited altered chemotactic activity, as evidenced by an inability to respond to secondary lymphoid-tissue chemokine (SLC/CCL21). Although no difference in chemokine expression was found between the spleens of infected versus control mice, chemokine production was greater in the livers of infected versus control mice. Collectively, these data indicate that Balb/c mice with 7-wk S. mansoni infection possess splenic T cells with altered chemotactic activity and that the alterations may be a consequence of the granulomatous response in the liver.

Title	Evidence of altered secondary lymphoid-tissue chemokine responsiveness in Balb/c mice infected with Schistosoma mansoni
Creator	Fried, Bernard
	Brault, M. S.
	Kurt, Robert A.
Publisher	Journal of Parasitology
Academic Department	Biology
Division	Natural Sciences
Organization	Lafayette College
Date Issued	2003
Date Available	2013-01-29T19:19:04Z
Type	Article
Language	English
Bibliographic Citation	Kurt, R. A., M. S. Brault, and B. Fried. (2003) "Evidence of altered secondary lymphoid-tissue chemokine responsiveness in Balb/c mice infected with Schistosoma mansoni." Journal of Parasitology 89 (4): 721-725.
Standard Identifier	Handle 10385/1069
Standard Identifier	DOI 10.1645/GE-92R
Permalink	http://hdl.handle.net/10385/1069
Rights Statement	In Copyright
Rights Holders	American Society of Parasitologists